5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
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5-HT1 Receptor
(448)
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5-HT2 Receptor
(473)
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5-HT3 Receptor
(31)
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5-HT4 Receptor
(12)
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5-HT5 Receptor
(12)
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5-HT6 Receptor
(85)
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5-HT7 Receptor
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
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5-HT Receptor Antagonists
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5-HT Receptor Activators
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5-HT Receptor Modulators
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1719)
Related Products (1719)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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RS-102221 hydrochloride (Standard)
0 ImagesCat. No.: HY-101365ARCAS No.: 187397-18-8RS-102221 (hydrochloride) (Standard) is the analytical standard of RS-102221 (hydrochloride). This product is intended for research and analytical applications. RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.
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DU125530
0 ImagesCat. No.: HY-19283CAS No.: 161611-99-0DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects.
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EMD386088 (Standard)
0 ImagesCat. No.: HY-103130RCAS No.: 1171123-46-8EMD386088 (Standard) is the analytical standard of EMD386088 (HY-103130). This product is intended for research and analytical applications. EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC50 of 34 nM). EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia.
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Melitracen-d6 hydrochloride
0 ImagesCat. No.: HY-108256SCAS No.: 1189648-08-5Melitracen-d6 (hydrochloride) is the deuterium labeled Melitracen hydrochloride. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space.
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5-Carboxamidotryptamine maleate (Standard)
0 ImagesCat. No.: HY-100942RCAS No.: 74885-72-6Synonyms: 5-CT maleate (Standard)5-Carboxamidotryptamine (maleate) (Standard) is the analytical standard of 5-Carboxamidotryptamine (maleate) (HY-100942). This product is intended for research and analytical applications. 5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist.
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Tiprenolol hydrochloride
0 ImagesCat. No.: HY-W181626ACAS No.: 13379-87-8Synonyms: DU 21445 hydrochlorideTiprenolol hydrochloride is a β-adrenoceptor blocker. Tiprenolol hydrochloride abolished ventricular arrhythmias induced by intravenous epinephrine in dogs receiving halothane inhalation.
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BMY 7378 (Standard)
0 ImagesCat. No.: HY-100554RCAS No.: 21102-95-4BMY 7378 (Standard) is the analytical standard of BMY 7378 (HY-100554). This product is intended for research and analytical applications. BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist.
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Tandospirone (Standard)
0 ImagesCat. No.: HY-14558RCAS No.: 87760-53-0Synonyms: SM-3997 (Standard)Tandospirone (Standard) is the analytical standard of Tandospirone. This product is intended for research and analytical applications. Tandospirone (SM-3997) is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.
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(±)-Fabesetron
0 ImagesCat. No.: HY-101638ACAS No.: 129299-72-5Synonyms: (±)-FK1052 free base(±)-Fabesetron ((±)-FK1052 free base) is the racemate of Fabesetron, which is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
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5-HT4R agonist-3
0 ImagesCat. No.: HY-184052CAS No.: 1809612-31-45-HT4R agonist-3 is a 5-HT4R agonist with an EC50 of 22 nM. 5-HT4R agonist-3 selectively modulates 5-HT4R and induces pro-cognitive activity. 5-HT4R agonist-3 can be used in research related to Alzheimer's disease.
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5-HT3 antagonist 3
0 ImagesCat. No.: HY-U00322CAS No.: 120635-47-45-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM.
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Zatosetron maleate
0 ImagesCat. No.: HY-U00234CAS No.: 123482-23-5Synonyms: LY 277359 maleateZatosetron maleate is a potent and selective 5HT3 receptor antagonist.
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Tertatolol
0 ImagesCat. No.: HY-U00356CAS No.: 83688-84-0Synonyms: (±)-Tertatolol; Racemic Tertatolol; dl-TertatololTertatolol is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects.
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(4E)-SUN9221
0 ImagesCat. No.: HY-U00367CAS No.: 222318-55-0(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
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5-HT3 antagonist 1
0 ImagesCat. No.: HY-U00368CAS No.: 129294-09-35-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor.
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5-HT3-In-1
0 ImagesCat. No.: HY-U00413CAS No.: 186348-68-55-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. It shows 5-HT3 inhibition activity.
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5-HT2 antagonist 1
0 ImagesCat. No.: HY-U00365CAS No.: 191592-09-35-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.
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5-HT3 antagonist 2
0 ImagesCat. No.: HY-U00408CAS No.: 128199-93-95-HT3 antagonist 2 is a 5-HT3 receptor antagonist.
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5HT6-ligand-1
0 ImagesCat. No.: HY-U00126CAS No.: 1038988-11-25HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM.
